Understanding Monoclonal Antibodies in Biotechnology.

The book delves deeply into the structure, types, functions, and gene organization of antibodies, with a specific focus on monoclonal antibodies (mAbs) that have revolutionized therapeutics and diagnostics. Different methods of generating chimeric, humanized, and fully human mAbs are explored, highlighting phage display, hybridoma, and rDNA technology. The book also delves into various recombinant antibody formats such as drug conjugates (ADCs, immunotoxins, and AAC), bispecific antibodies (scFv based and Full-length IgG based), abzymes, Antibody-directed enzyme prodrug therapy (ADEPT), Fc-fusion proteins, and single-domain antibodies (VHH and IgNAR sdAb).

Therapeutic applications of monoclonal antibodies are discussed in great detail, along with immunogenicity concerns, modes of administration, and potential side effects. The challenges and obstacles encountered in developing mAbs into therapeutic agents are also examined. Researchers' efforts to decrease immunogenicity and enhance therapeutic mAb efficacy are highlighted throughout the book.

This comprehensive resource caters to researchers and students in biology, medicine, biotechnology, immunology, genetics, and molecular biology, as well as individuals interested in antibody engineering. The book not only provides a thorough understanding of monoclonal antibodies but also offers insights into the latest advancements and innovations in the field.

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